Intravenous & Chelation Therapy

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 Health Care & Cancer                Therapy

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New scientific studies published by researchers at the National Institutes of Health (NIH) have revealed that the use of intravenous vitamin C may play a powerful role in cancer treatment.
IV /Chelation Therapy
 Newer scientific studies published by researchers at the National Institutes of Health (NIH) have revealed that the use of Infusion or intravenous vitamin C may play a powerful role in cancer treatment.

In the 1970s, Dr. Linus Pauling noted that the administration of vitamin C was beneficial for cancer patients, but researchers from the Mayo Clinic later debunked his theory after they claimed to have repeated his studies and noted no benefit. As a result, interest in the use of vitamin C in cancer declined.

However, the Mayo Clinic had not actually repeated Pauling's studies. In most of their studies, they had administered vitamin C by mouth while Pauling had been using intravenous vitamin C. So, in fact, the routes of administration were vastly different. And now, we know that oral and intravenous vitamin C are not absorbed the same.

Dr. Mark Levine, Chief of the Molecular and Clinical Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases of the NIH, found that while oral intake of vitamin C reaches a saturation point, "when you give doses intravenously, they go through the roof in the blood and then they are cleared."

In studies published in September, 2005 and March, 2006, Dr. Mark Levine and his colleagues at the NIH published key papers requesting that the role of high-dose intravenous vitamin C therapy in cancer patients be reassessed. They found that when administered intravenously, blood levels of vitamin C could be 50 to 70 times higher than the maximum concentrations achieved with the oral dosage alone. Furthermore, they concluded that the intravenous administration could selectively kill cancer cells (or infectious agents) without harming normal cells.


By NORLEENA GULLETT, MD

Oct. 17, 2012

It's a decision that millions of Americans face every morning: to take, or not to take, that multivitamin. Now, a new study of almost 15,000 men over 50 suggests popping that daily supplement could cut cancer rates by 8 percent.

The study is good news for some Americans, who spend billions of dollars each year on the assumption that taking a daily multivitamin will help prevent disease.
Integrative medicine
Chelation therapy
:

What To Do With Inconvenient Evidence 

Harlan M Krumholz MD, professor of cardiology

Mar 27, 2013
What do we do with inconvenient evidence? Imagine studying a seemingly absurd practice that is used to an alarming extent by those who believe in it despite the lack of evidence and finding that the intervention improves outcomes. And imagine that the people conducting that trial are famous scientists with impeccable credentials who have extensive experience with this type of investigation.

Harlan M. Krumholz, M.D., S.M. is a practicing cardiologist and the Harold H. Hines, Jr. Professor of Medicine.(Cardiology) Professor of Investigative Medicine and of Public Health (Health Policy); Director, Clinical Scholars Program; Director, Yale-New Haven Hospital Center for Outcomes Research and Evaluation. 


              about this authohttp://medicine.yale.edu/intmed/people/harlan_krumholz-1.profile


Imagine that the practice is so out of the mainstream that the investigators cannot even posit how the treatment could reduce patient risk?

We live in a world of evidence-based medicine, where we are urged to base our medical recommendations and decisions on clinical studies. We base our guidelines on the medical literature and evaluate our practices by how well we adhere to the evidence. But what should we do with inconvenient evidence?

The National Institutes of Health sponsored a $31 million trial of chelation therapy, a therapy that involves the infusion of vitamins and a substance that binds certain minerals, such as calcium.

Some practitioners embraced this therapy and have recommended it for patients with heart disease.

                 Note: Please see Chelation video upper left corner of this article

Although I never learned about it in my training as a cardiologist, it is quite widespread with reportedly more than 100,000 people using it in 2007, an increase of 68% from 2002.

Thinking about chelation? Call and schedule a free consultation to learn more about it or set up an appointment. Call 732-255-8880.Here at theToms River Wellness center.

The trial, published in JAMA, compared 839 patients who had a heart attack. They randomized these individuals to chelation with 869 to a placebo infusion. To the surprise of many (including me), after almost 5 years of follow-up, the chelation group had a lower risk of the combination of death, heart attack, stroke, hospitalization for angina or a procedure to improve blood flow to the heart.

There was an 18% lower risk in the chelation group and for about every 25 patients treated with chelation, there was one few adverse event. Also, there were no safety issues. This trial, like most others, has some limitations but it is a positive trial.

The authors, who are quite esteemed, seemed surprised. They noted that no one knows how this therapy works. They said that the results were not strong enough to support the routine use of chelation therapy. It is not clear what they mean by routine they seem unable to make a strong recommendation – as if they have some uncertainty how to act on what they found.

The irony is that if a drug manufacturer had gotten this result, they would have celebrated. We have billion dollar drugs like niacin and fenofibrate and ezetimibe that have less evidence than chelation therapy has now. None of those drugs has contemporary outcomes studies showing benefit – and 2 of them (niacin and fenofibrate) have 2 recent negative trials.

So why are scientists not accepting the verdict of this study? Why the reluctance to incorporate this therapy into our armamentarium?

The answer is more than just a reluctance to accept results that we do not like (though medicine is not beyond that behavior see the slowness with which medicine adopts new information into practice). I believe that the answer here is that when confronted with a truly surprising result that is hard to explain. In this situation we need to examine our assumptions and the consequences of being wrong. 

The amount of evidence we require may vary based on the treatment. For example, I am more likely to demand strong evidence for the use of treatments that may cause risks and incur substantial costs except perhaps in dire circumstances where no alternatives exists and in these cases we need to be able to track the effect after approval and spread so that the interventions can be reassessed over time. And I may want stronger empiric evidence where I have no underlying expectation that a treatment would be beneficial based on previous studies or the absence of previous studies.

If we have little faith in chelation therapy, then it is hard to turn 180 degrees with a positive result and suddenly completely believe in it and recommend its use. Any trial can give an anomalous result and we need to be careful about jumping to a new position with each new piece of evidence. However, we cannot on one hand promote evidence-based medicine and on the other hand ignore what we do not like.

I am glad that we are subjecting popular but out of the mainstream practices to rigorous study. If I endorse that course I cannot ignore the evidence because it goes against what I expected. But I need to interpret the findings through the totality of what is known about it and determine if it is really ready for prime time.

In this case, I want to see more studies of this approach to be sure. However, this study has opened my mind to the possibility that there may be something more to this therapy than I originally thought. And given what I thought about it before, I can hardly believe I am writing that.
Chelation therapy
3 min 52 sec
Vitamin C & cancer
1 min 17 sec